The launch of the Translational Perioperative and Pain Medicine

William T.G. Morton, on October 16, 1846, demonstrated the use of ether anesthesia at the Massachusetts General Hospital. He opened a gateway to the translational medicine in modern anesthesiology and perioperative medicine. However, it took over 100 years before this compound was utilized for anesthetic purposes and eventually, the role of ether in modern medicine was replaced with safer drugs such as sevoflurane, desflurane, etc. Despite these drugs are essential for modern anesthesia, the underlying mechanism of general anesthetics remain elusive(1) and true neurological outcomes are currently a hot topic of debate/research in aged brain and neonatal brain.(2,3) Further studies are warranted and novel anesthetics with minimal side effects are to be discovered and developed.